CLA, or conjugated linoleic acid, is a chemical variant of an Omega-6 fatty acid that, according  to   recent  research,   may  have  anticarcinogenic and growth-enhancing properties. Of  greater importance to researchers and dieters alik is CLA's apparent ability to manipulate the activity of certain enzymes, which in effect release more fat into the bloodstream. Once there, fat can be transported to other cells and burned as fuel.

In a study examining these effects, 80 obese people were instructed to maintain a healthy diet and exercise, and their weight and body composition were monitored for 6 months. Several subjects lost as much as 5 pounds, but regained most or all of that weight. However, those study participants who took CLA retained an even ratio of muscle and fat over the six months, while those who did not take the supplement put pounds back on at the more typical ratio of 75% fat to 25% lean mass.
Since it's extremely difficult to get enough of this compound from whole foods to take advantage of its positive effects, supplementing with CLA may complement a well-rounded exercise and nutrition program. The following chart examines the results of a three-month, randomized, double-blind study of CLA's effect on bodyfat percentage in 20 healthy people.